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Friday, July 31, 2020 | History

2 edition of Airway Responsiveness and Exhaled Nitric Oxide found in the catalog.

Airway Responsiveness and Exhaled Nitric Oxide

Dora Ludviksdottir

Airway Responsiveness and Exhaled Nitric Oxide

Studies in Asthma and Sjogren"s Syndrome (Comprehensive Summaries of Uppsala Dissertations, 857)

by Dora Ludviksdottir

  • 158 Want to read
  • 8 Currently reading

Published by Uppsala Universitet .
Written in English

    Subjects:
  • Research,
  • Medical

  • The Physical Object
    FormatPaperback
    ID Numbers
    Open LibraryOL12854105M
    ISBN 109155445128
    ISBN 109789155445126

    Induced sputum and exhaled nitric oxide are well established as direct markers of inflammation for use in asthma research. Sputum can be induced from children of >6 yrs using inhalation of hypertonic saline, and, if appropriate, can be combined with an assessment of airway responsiveness to hypertonic saline. To investigate the utility of the determination of airway responsiveness to inhaled adenosine 5′-monophosphate (AMP) and exhaled nitric oxide (ENO) levels as markers for safely reducing the dose of inhaled corticosteroids (ICS) in patients with asthma well .

    Introduction. A relationship between the fraction of exhaled nitric oxide (FeNO) and asthma was demonstrated in the s with the finding of elevated FeNO in patients with asthma.1–3 Further research suggested that FeNO was potentially a non-invasive marker of eosinophilic airways inflammation,4 5 with increased levels being seen with increasing allergen exposure.6 7 . In medicine, exhaled nitric oxide (eNO) can be measured in a breath test for asthma or other conditions characterized by airway inflammation. Nitric oxide (NO) is a gaseous molecule produced by certain cell types in an inflammatory response. The fraction of exhaled NO (FE NO) is a promising biomarker for the diagnosis, follow-up and as a guide to therapy in adults and .

    Combined use of exhaled hydrogen peroxide and nitric oxide in monitoring asthma. Am J Respir Crit Care Med –, Crossref | PubMed | ISI Google Scholar; 19 Horvath I, Donnelly LE, Kiss A, Paredi P, Kharitonov SA, and Barnes PJ. Chemiluminescence analyzers measure the concentration of nitric oxide (NO) in exhaled breath as a marker of airway inflammation. Specifically, the NIOX system uses a chemiluminescence gas analyzer than can measure low concentrations of NO. The device is calibrated between 0 and parts per billion (ppb) for exhaled NO.


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Airway Responsiveness and Exhaled Nitric Oxide by Dora Ludviksdottir Download PDF EPUB FB2

Background: Exhaled nitric oxide (FENO) is raised in asthmatic children, Airway Responsiveness and Exhaled Nitric Oxide book there are inconsistencies in the relationship between FENO and characteristics of asthma, including atopy, increased airway responsiveness (AR), and airway inflammation.

The aim of this study was to investigate the relationship between FENO and asthma, atopy, and Cited by: Background: Exhaled nitric oxide (FE NO) is raised in asthmatic children, but there are inconsistencies in the relationship between FE NO and characteristics of asthma, including atopy, increased airway responsiveness (AR), and airway inflammation.

The aim of this study was to investigate the relationship between FE NO and asthma, atopy, and increased AR in by:   Study objectives. To determine the effect of cessation of exposure to pollen on airway responsiveness to adenosine 5′-monophosphate (AMP) in subjects with pollen-induced rhinitis, and to explore the relationship between changes in airway responsiveness and changes in exhaled nitric oxide (ENO) by:   To this end, we selected subjects with pollen-induced asthma to measure the effect of 6 weeks of treatment with salmeterol and placebo on allergen-induced airway responsiveness to methacholine and AMP and on allergen-induced changes in exhaled nitric oxide (ENO) concentrations during natural pollen by:   Exhaled nitric oxide (F eno) has been proposed as a noninvasive marker of airway inflammation in asthma.

1 F eno levels are elevated in asthmatics, 2 fall after treatment with corticosteroids, 3 and have been positively correlated with eosinophils in sputum 4 and BAL fluid. 5 These observations have prompted suggestions that measurement of F eno may be Cited by: Exhaled nitric oxide, a product of the action of proinflammatory cytokines, was also measured to assess the contribution of local inflammation to airway responsiveness.

The cough responses to low-concentration chloride solutions and to capsaicin were studied. associated with airway inflammation than the re-sponse to direct bronchoconstrictors such as hista-mine or methacholine.

Exhaled nitric oxide (ENO) levels are known to be increased in patients with asthma,16 Nitric oxide is a messenger molecule generated from L-arginine by the action of several distinct enzymes called nitric oxide synthases.

Prieto L, Gutiérrez V, Torres V, Uixera S, Marin J. Effect of salmeterol on seasonal changes in airway responsiveness and exhaled nitric oxide in pollen-sensitive asthmatic subjects.

Chest. ; –   Nitric oxide (NO) is an important regulator of immune responses and is a product of inflammation in the airways that is over-produced in asthma. Fractional exhaled NO (FeNO) is predominantly used as a predictor of response to inhaled corticosteroids (ICSs), to monitor adherence and as a diagnostic tool in ICS-naïve patients.

BACKGROUND Airway hyperresponsiveness, induced sputum eosinophils, and exhaled nitric oxide (NO) levels have all been proposed as non-invasive markers for monitoring airway inflammation in patients with asthma. The aim of this study was to compare the changes in each of these markers following treatment with inhaled glucocorticosteroids in a single study.

Gratziou C, Lignos M, Dassiou M, Roussos C. Influence of atopy on exhaled nitric oxide in patients with stable asthma and rhinitis. Eur Respir J. Oct; 14 (4)– Lúdvíksdóttir D, Janson C, Högman M, Hedenström H, Björnsson E, Boman G.

Exhaled nitric oxide and its relationship to airway responsiveness and atopy in asthma. Fractional concentration of exhaled nitric oxide (FENO) is a biomarker used to identify allergic airway inflammation.

Because it is noninvasive and easy to obtain, its utility has been studied in the diagnosis and management of several respiratory diseases. Much Cited by: Nitric oxide (NO) is an important regulator of immune responses and is a product of inflammation in the airways that is over-produced in asthma.

Fractional exhaled NO (F eNO) is predominantly used as a predictor of response to inhaled corticosteroids (ICSs), to monitor adherence and as a diagnostic tool in ICS-naïve patients. Significant correlation has been found between exhaled NO and skin test scores in steroid naive asthmatic patients, allowing to discriminate patients with and without airway responsiveness.

Exhaled NO is significantly elevated in acute asthma, or steroid‐resistant severe asthma, or when the maintenance dose of inhaled steroids is reduced, and. S.A. Kharitonov, D. Yates, P.J. BarnesIncreased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections Eur.

Objectives. To investigate the utility of the determination of airway responsiveness to inhaled adenosine 5′-monophosphate (AMP) and exhaled nitric oxide (ENO) levels as markers for safely reducing the dose of inhaled corticosteroids (ICS) in patients with asthma well controlled with a moderately high ICS dose.

Objectives: To compare the effects of esomeprazole 40 mg bid and fundoplication on airway responsiveness, forced expiratory volume in 1 s (FEV1), exhaled nitric oxide (NO) and respiratory symptoms in patients with moderate-to-severe GORD. Endogenously produced nitric oxide (NO) in exhaled air of animals and humans was first measured by Gustafsson et al.

1, and it was suggested early that the concentration of exhaled NO may reflect airway inflammation, thus offering a noninvasive method to assess inflammatory airway diseases 2–ing a bronchial allergen challenge there is an elevation of exhaled.

The measurement of exhaled nitric oxide for the management of asthma and/or other respiratory disorders is considered experimental, investigational or unproven due to insufficient evidence of beneficial health outcomes.

General Background. Fractioned exhaled nitric oxide (FENO) is the amount of nitric oxide (NO) present in the airways that is. Methods. We used a microarray platform to analyze bronchial airway epithelial cell gene expression in relation to the asthma biomarker fractional exhaled nitric oxide (F e NO) in subjects with asthma and healthy control subjects from the Severe Asthma Research Program (SARP).

Objectives: To investigate the utility of the determination of airway responsiveness to inhaled adenosine 5'-monophosphate (AMP) and exhaled nitric oxide (ENO) levels as markers for safely reducing the dose of inhaled corticosteroids (ICS) in patients with asthma well controlled with a moderately high ICS dose.

Methods: A total of 37 patients with asthma well controlled .Exhaled nitric oxide. Exhaled nitric oxide measurements were performed using a Logan Research analyser (Logan Research Ltd, Rochester, Kent, UK) which operates on the principle of chemiluminescence.

The technique used was that recommended by the European Respiratory Society Task Force. Histamine inhalational challenge.Airway responsiveness to histamine bronchoprovocation (PD20 -FEV1) and exhaled nitric oxide (FeNO) was determined. Results: NAR increased significantly in all subjects with the greatest effect seen in AR+AHR+ individuals.